| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
High susceptibility of activated lymphocytes to oxidative stress-induced cell death
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| Autores: |
Degasperi,Giovanna R.
Castilho,Roger F.
Vercesi,Anibal E.
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| Data: |
2008-03-01
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| Ano: |
2008
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| Palavras-chave: |
Cell death
Free radicals
Immune response
Lymphopenia
Mitochondrial permeability transition
Spleen lymphocyte
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| Resumo: |
The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin A, but not the calcineurin inhibitor FK-506, render control and activated lymphocytes equally resistant to the toxic effects of t-BOOH. Incubation of activated lymphocytes in the presence of t-BOOH resulted in a cyclosporin A-sensitive decrease in mitochondrial membrane potential. These results indicate that the higher cytosolic Ca2+ level in activated lymphocytes increases their susceptibility to oxidative stress-induced cell death in a mechanism involving the participation of mitochondrial permeability transition.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100009
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652008000100009
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.80 n.1 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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